Patients present with advanced or metastatic renal cell carcinoma (RCC) in different ways

Advanced or metastatic RCC is kidney cancer that has spread beyond the kidney, including the lymph system, adrenal gland, or other organs such as the lungs, brain, bones, or liver.¹

Kidney cancer: A snapshot^2,3

Advanced RCC occurs in approximately 68,000 to 101,000 cases of the 338,000 global cases of kidney cancer each year
2 to 3 times more common in men than in women
Incidence of RCC increases steadily after age 40
Kidney cancer is on the rise

Symptoms^3,4

Blood in the urine
Low back pain on one side
Abdominal pain
A mass (lump) on the side or lower back
Fatigue
Loss of appetite
Weight loss without dieting
Fever without infection
Anemia

For patients diagnosed with advanced or metastatic RCC, a targeted therapy that has limited impact on their quality of life is meaningful

See prolonged progression-free survival

See head-to-head first-line data in advanced RCC

References: 1. Robertson S. Metastatic renal cell carcinoma. News Medical Life Sciences website. http://www.news-medical.net/health/Metastatic-Renal-Cell-Carcinoma.aspx. Updated July 19, 2016. Accessed December 16, 2016. 2. Petejov N, Martinek A. Renal cell carcinoma: review of etiology, pathophysiology and risk factors. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016;160(2):183-194. 3. Eble JN, Sauter G, Epstein JI, Sesterhenn IA, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon, France: IARC Press; 2004. 4. Kidney cancer (adult) - renal cell carcinoma. American Cancer Society website. http://www.cancer.org/acs/groups/cid/documents/webcontent/003107-pdf.pdf. Updated May 16, 2016. Accessed December 7, 2016.

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